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Agonist is often referred to as a drug that stimulates natural processes in the body and beta-2 to a cell receptor

However, those drugs are only FDA-approved to treat type 2 diabetes (along with diet and exercise), not obesity

Different isoforms of APX show differential response to environmental stresses, depending upon their sub-cellular localization, and the presence of specific regulatory elements in the upstream regions of the respective genes

These factors often remain undetected without proper evaluation, making early diagnosis essential for effective treatment

Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition