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Nearly 60 years ago Toronto physician William McCormick observed that cancer patients often presented with severely low levels of vitamin C in their blood and featured scurvy-like symptoms, leading him to postulate that vitamin C might protect against cancer by increasing collagen synthesis

& Jarstrand, C

and an extracellular copper, zinc superoxide dismutase (SOD3) [23, 112]

This correlation facilitates the classification of responses into two distinct categories: adaptive eustress and detrimental distress