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doi: 10.1111/j.1528-1167.2006.00830.x 48

Evening dosing encounters circadian suppression of autophagy (driven by PER2 gene expression), lower p53 protein levels due to peak MDM2 ubiquitin ligase activity, and potential interference from postprandial insulin signaling if dosed within 4 hours of eating

211 Another study examined whether consumption of cereal grains fortified with tryptophan improved the sleep-wake cycle in 35 individuals age 5575 years