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On the other hand, there are research results showing that, in contrast to healthy subjects, no increases in reactive nuclear factor (NF)-kB activation, interleukin-1beta (IL-1) production, antioxidant proteins (thioredoxin [TRX], Mn-SOD, heme oxygenase1 [HO-1]), or stress-protective proteins (heat shock protein-70 [HSP-70]) occurred in the quadriceps femoris muscle when COPD patients engaged in acute exercise loading [32]

Tumor mutational burden, toxicity, and response of immune checkpoint inhibitors targeting PD(L)1, CTLA-4, and combination: a meta-regression analysis

Danpanichkul et al., 2024)