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Research protocol (based on published studies): Dose: Varies by study

In line with the repression of KEAP1, total and phosphorylated NRF2 proteins were upregulated in Cis_NR J82 and T24 cells

TB-500 is the synthetic version used therapeutically

10.1515/CCLM.2007.021 53

8,14 The primary method for accomplishing this is diet, exercise, and lifestyle measures, although in indicated cases bariatric surgery has proven remarkably successful when a more conservative approach does not suffice