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Methods Data processing and Oligodendroglial gene enrichment Data Selection: transcriptomic datasets were selected from single-cell and bulk-transcriptomic studies generated in neural cell types during mouse development at the embryonic, postnatal, and adult stages 31,32,33,34,35,36

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The cell line was further stably transfected with receptor modifying protein 3 (RAMP3) thus generating the human amylin 3 (a) receptor (hAMY 3(a) R)

The mPEG-b-PLLA resulted in improved cellular uptake and greater functionalization in vitro

If more than 3 days have passed, skip the missed dose and take the next scheduled dose