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Evidence indicates that using recombinant adeno-associated virus AAV9 in combination with a TGF-/Smad inhibitor can effectively mitigate silicosis-induced PF through ferroptosis inhibition [111]

Different mechanisms have been proposed in different cellular, organ, and animal models, including transcellular and paracellular routes

This effect of MT-1G is achieved by blocking the GSH depletion-mediated lipid peroxidation to inhibit ferroptosis in HCC cells, independent of iron ion content