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As an alternative chemotherapeutic agent, AMPs/ACPs display several extraordinary properties such as broad spectrum activity, high specificity, rapid mode of action, efficient tumor penetration due to small size, good solubility, low toxicity, ability to bypass the multidrug-resistance mechanism induced by tumor cells against conventional chemotherapy drugs and finally capability to produce in commercially available scale and make AMPs/ACPs as suitable candidates for the development of novel anticancer agents

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Immunology 141 , 7995 (2014)

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Nucleic acid-based delivery systems Aptamers, synthetic single-stranded DNA or RNA oligonucleotides that fold into defined three-dimensional architectures enabling high-affinity target recognition, have emerged as versatile modules for constructing targeted PROTAC delivery systems [230,231,232]