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The changes in the microenvironment of the retina caused by oxidative stress, inflammatory response and other factors affect the occurrence and development of DR (5,6)

Tryptophan can be converted to indole-3-pyruvate (I3P) by interleukin-4-induced-1 (IL4i1), which protects cancer cells from ferroptosis through scavenging lipophilic radicals, increasing the GSH/ Glutathione disulfide (GSSG) ratio, upregulating the expression of SLC7A11 and targeting some genes in the antioxidant signaling pathway, such as hemeoxygenase-1 (HO-1) [87]

Because if not, if it dissociates to any extent, it seems it could then be absorbed, and, at least according to Cutler, this could provoke redistribution as the ALA is not being given according to its half life