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Description

NAD+-metabolizing ectoenzymes in remodeling tumorhost interactions: the human myeloma model

Conditions that shorten red cell lifespan such as haemolytic anaemia or acute blood loss mean cells spend less time in circulation and accumulate less glycated haemoglobin, producing a spuriously low HbA1c even when blood glucose is elevated

Reactions were performed with 5 M histone H3 (histone L-arginine) substrate, 1 M radiolabeled S-adenosyl-L-[methyl-3H]methionine (SAM) co-substrate, and recombinant human PRMT3 enzyme