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Testing: Match the Test to the Question Diet and DAO assessment Use a structured food trial, symptom diary, review of gut disease, medication effects and possible DAO support

PLoS ONE 4 , e5682 (2009)

Detoxification: Lifestyle changes, such as reducing exposure to toxins and increasing hydration

Glutamine synthesis increases in vivo during acute hyperammonemia, acting as a mechanism for detoxifying excess ammonia, and induces the excessive activation of NMDA receptor, which causes death via acute ammonia poisoning (Marcaida et al., 1992

While various hypotheses have been proposed to explain the release of mtDNA, including alterations in mitochondrial permeability transition, changes in mitophagy, and shifts in mitochondrial dynamics, the precise mechanism remains unclear [45]