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By definition, CMPs are the subset of progenitor cells that are capable of generating all myeloid cells (that is, monocytes, macrophages, dendritic cells, erythrocytes, megakaryocytes, platelets, basophils, eosinophils and neutrophils) under appropriate cytokine stimulation, but that are no longer capable of generating cells of the lymphoid lineages (such as B cells, T cells and NK cells)

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These neuronal activation patterns are attenuated or absent in RAMP1/RAMP3 knockout animals, further implicating AMYR and AMYR as the functional receptors mediating these central effects

For instance, deficiencies in both could cause fatigue, but nerve pain was unique to B12, and bone pain was associated with a D deficiency

Free B12 forms a complex with intrinsic factor (IF), a glycoprotein produced by the stomachs parietal cells