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Indeed, hypoxic regions exist within the normal renal medulla (86) and renal tumors (87), and adaptation of cancer cells to SSH may contribute to kidney cancer progression (Table III)

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Disturbances in GSH homeostasis have been implicated in neurodegenerative disorders, liver disease, cystic fibrosis, pulmonary and cardiovascular diseases, as well as the chronic age-related diseases and the aging process itself.Recent data also suggests it plays a role in metabolic and inflammatory diseases such as multiple sclerosis, the metabolic syndrome, and diabetes, at least in part by influencing the effect of multiple environmental toxins, an underappreciated yet surprisingly significant association

Further studies are needed in future to clarify the mechanisms by which topical GSSG produces these skin benefits

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