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Trofinetide: First Approval

The zinc finger transcription factor Sp9 is required for the development of Striatopallidal projection neurons

Specifically, two-way ANOVA with Tukeys multiple comparisons test was applied for the behavioral assessments (Rotarod, Actophotometer, and Balance Beam tests), and one-way ANOVA with Dunnetts multiple comparisons test was used for the biochemical assays (GSH, MDA, SOD)

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Ricciardi MR, Scerpa MC, Ciuffreda L, Chiaretti S, Tavolaro S, Gervasoni J, De Cave F, Gregorj C, Petrucci MT, Del Bufalo D, Cognetti F, Andreeff M , Zupi G, Foa R, Tafuri A, Milella M