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For all other participants, Table 2 and Figure 2a shows the level of urinary excretion of toxic metals (normalized per gram creatinine) at baseline (beginning of Phase 1, before taking any DMSA), and after the first and 9 th doses of DMSA in the Phase 1 challenge round

The Medical Ethical Committee of the AMC provided a letter of no objection to perform the study as formal consent of patients is not required in the Netherlands for retrospective studies

FIGURE 2 TIRAP (toll/interleukin-1 receptor domain-containing adapter protein) recruits MyD88 (myeloid differentiation factor 88) directly to the TLR4 cytoplasmic domain

The typical course for B12 shots is to give a few injections in the first month (one per week) at 1000mcg per shot and then start to spread them out