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Cagrilintide works through an entirely separate system, the amylin receptor pathway, targeting different neuronal populations in the brainstem that regulate satiety and appetite

This difference is likely to be related to the more tightly packed ECD interface of RAMP2 and CTR, driven by the interactions with P37 Cagri , and the preferential CTR engagement by Cagri via a bypass conformation, as discussed below in the context of CTR complexes

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