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An alternative possibility is that reduced EAAT3 function leads to a maldistribution of glutamate, perhaps altering the synaptic-extrasynaptic glutamate ratio, and the ratio of NMDA activation, in particular brain circuits, and thereby leads to functional circuit abnormalities that fall short of neuronal death

PMID: 41 JanjetovicZJarrettSGLeeEFDupreyCReiterRJSlominskiAT