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Areas such as deep abdominal fat (visceral adipose tissue) and lower body subcutaneous fat often demonstrate resistance to traditional fat loss approaches due to lower concentrations of beta-adrenergic receptors and higher concentrations of anti-lipolytic alpha-2 adrenergic receptors

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At the transport level, lactate achieves dynamic intracellular-extracellular and intercellular exchange through the MCT family (such as MCT1 and MCT4), a process mediated by factors such as pH, lactate concentration gradients, and cellular redox reactions [70]

Nature 544 , 372376 (2017)

The FDA had set an initial target date of Aug