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10.1161/JAHA.120.018633 Summary Keywords intracranial aneurysm, DNA methylation, mRNA expression, 5-aza-2'-deoxycytidine, glutathione S-tranferase alpha 4 Citation Xu T, Yu X, Zhou S, Wu Y, Deng X, Wu Y, Wang S, Gao X, Nie S, Zhou C, Sun J and Huang Y (2023) DNA methylation and mRNA expression of glutathione S-transferase alpha 4 are associated with intracranial aneurysms in a gender-dependent manner

GA decreases the activity of catalase (CAT), ascorbate peroxidase (APX), and superoxide dismutase (SOD), leading to reduced scavenging ability for ROS, consequently resulting in peroxidative damage of membranes followed by release of hydrolytic enzymes (Jones and Smirnoff, 2005

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