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The free L- Asp was analyzed by mass spectrometry to determine the change in the ratio of protiated to deuterated substrate, being repeated for each of the different L-Asp:K258A stoichiometries

Notably, current strategies targeting lipids are not brain-specific and affect peripheral lipid biosynthesis, which is associated with increased triglyceride levels and side effects such as liver steatosis [219]

This study found that the percentage of subjects in three age groups (26 to 49y, 50 to 64y, and 65y and older) with deficient blood levels of vitamin B12 was similar across all age groups but that symptoms of B12 deficiency were not as apparent in younger adults