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Whatever you do, DO NOT SHAKE THE VIAL

What do you make of anecdotal reports found on social media

This is often as a result of sudden forceful contraction or a direct blow to the knee

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In a randomized controlled trial, 44 obese or overweight women treated with 80 mg of pyridoxine hydrochloride (a form of vitamin B6) for eight weeks experienced improved insulin sensitivity and decreased fat mass compared with placebo (Haidari 2021)