Farr and Xiong, 2021)
Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis
(2016) found that the 5-fluorouracil loading within -cyclodextrin-based metalorganic framework-1 by 0.257 g/g was higher than -cyclodextrin-based metalorganic framework-2 by 0.107 g/g owing to the larger cavities of -cyclodextrin-based metalorganic framework-1
The molecular docking was performed based on the CB-Dock-2 tool ( CB-Dock-2 is a protein-ligand docking method that automatically identifies binding sites, calculates the center and size, customizes the docking box size based on the query ligands, and then performs molecular docking using AutoDock Vina [17]
They observed that metformin could downregulate the expression of MMP-9/MMP-2 and mTOR while upregulating the expression of protein kinase B and adenosine monophosphate-activated protein kinase (AMPK), thereby inhibiting ovarian granulosa cells dysfunction and promoting their recovery of follicle function ( in vitro studies utilizing human granulosa tumor-derived cell models demonstrates that metformin intervention effectively downregulates multiple components of the LPS-activated inflammatory cascade, including LPS-induced miR-670-3p , NOX2 , NLRP3 , ASC , and GSDMD-N , as well as reducing cellular caspase-1 activity, ROS production, and secretion of inflammatory factors
