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12 Current challenges in glutathione detection and biomarker analysis Quantification of GSH and related biomarkers like oxidized glutathione (GSSG) and the GSH/GSSG ratio is both clinically and research-wise challenging, predominantly due to preanalytical instability, methodological diversity, and biological interpretation difficulty

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In an ovarian cancer xenograft model, administration of sulindac (7.5 mg/kg/day for four weeks) led to approximately 70% reduction in tumor volume