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Concurrently, 4-OI reduces the levels of proinflammatory cytokines including TNF- and IL-1 in peripheral blood mononuclear cells and suppresses NF-B activity [63]

IGFBP-2 causes the inactivation of protein tyrosine phosphatase (RPTP-) by binding to the RPTP- receptor and subsequently inhibits the transcription of the tumor suppressor gene PTEN

10.1002/adhm.202303674 203 LiaoB.QiaoJ.PangY

As hematogenous transmission predominates in lung metastasis, vascular endothelial surface proteins critically mediate metastatic tropism [117, 118]

Their advantageous properties, including low molecular weight, minimal immunogenicity, facile chemical synthesis, robust tissue penetration, and an expansive target scope, position them as compelling alternatives to antibodies for addressing the cardinal limitations of PROTACs, namely poor selectivity, off-target toxicity, and inadequate delivery efficiency (Fig