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Considering all this, its not too surprising that high levels of homocysteine have been linked to many chronic neurodegenerative and neuropsychiatric diseases, including: Depression (105-111) Dementia, Alzheimers disease , cognitive impairment/dysfunction/decline (119-133, 143) Headaches and migraines (112-118, 148) Hearing loss (136-137) Brain atrophy (134, 144, 151) Parkinsons disease (145) Stroke (154-155) Postpartum depression (135) Postmenopausal mental decline (146) Schizophrenia and other affective disorders (147, 153, 156) Alcoholism (149) Multiple sclerosis (158-161) People with nutritional deficiencies and MTHFR gene mutation are at an increased risk of high homocysteine levels

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In this paper, we will discuss how hematologic and oncologic diseases are associated with disruption in the intestinal barrier and explore the consequences of an increase in the intestinal permeability in these patients