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In this work, we explored the biological effect of nano-SARs, by developing a microenvironment-responsive in vivo self-assembled peptide-ferriporphyrin conjugates ( Gi-F-CAA ) for improving tumor penetration, accumulation and binding affinity with GPX4, ultimately synergistically enhancing ferroptosis-based anticancer activity

McIntyre RL, Molenaars M, Schomakers BV, Gao AW, Kamble R, Jongejan A, et al

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Therefore, IGF-1 may indirectly modulate carbohydrate metabolism through GH suppression and enhancement of insulin action