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The cells (3105) were seeded into 6-well plates and incubated for 24 h, prior to the addition of fresh culture medium for 24 h and collection of the supernatant

National Toxicology Program, Research Triangle Park, NC

Recent studies have shown that myofibroblasts can be derived not only from tissue-resident fibroblasts, but also from hepatic stellate cells (HSC), endothelial cells, pericytes, and smooth muscle cells, through process such as epithelial-mesenchymal transition (EMT) and endothelial-mesenchymal transition (EndoMT) [29,30,31,32] (Fig

R., Zimmerman, M

Patients who were treated for more than 2 years were given the option to take a treatment break