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Clinical trials predominantly document mild and self-limiting adverse effects such as abdominal distension, lower limb hypoesthesia, and transient pain exacerbation, which typically resolve without necessitating extensive medical intervention [4, 21, 25, 26, 66]

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The transferrin ligand itself, along with engineered peptides such as the T7 peptide (HAIYPRH), has demonstrated strong affinity for TfR

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