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If anxiety, depression, hallucination, seizures, cranial nerve weakness, and paresis of the extremities are associated with vomiting and abdominal pain, detection of increased urinary -aminolevulinic acid and porphobilinogen in spot urine during the episode confirm the diagnosis of acute intermittent porphyria

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Unique role of IGF-1R in cancer The IGF-1R is a phylogenetically conserved receptor TK and belongs to the insulin receptor family, involving also the insulin receptor (IR), hybrid receptors and the IGF-2R/mannose 6-phosphate receptor

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