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doi: 10.1016/j.biotechadv.2016.11.002 29 KimSJKimEMYamamotoMParkHShinH

To overcome these bottlenecks and advance this therapy towards clinical application, stem cell-based regenerative treatment for IVD is entering a new phase, with future efforts focusing on the following key directions: First, personalized therapy will become the cornerstone

PMCID: PMC8125908

Bhatia M

The cyclobutanone intermediate formed undergoes rapid enolization followed by esterification with another equivalent of acid chloride to give the key compound which is the cyclobutenol ester