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Systems pharmacology has emerged as a crucial approach for identifying the biological targets and chemical compounds of drugs that influence network interactions within the body, as it highlights the extensive nature of drug interactions, aligning well with the multi-target and multi-pathway features inherent in natural products [23, 24]

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Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse

The RAAS is considered to be a major activator of NADPH oxidase and ROS production in hypertension

Glutathione synthesis also requires dietary glutamate and glycine