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Dysbiosis in the gut microbiota is known to disrupt immune homeostasis, leading to abnormal immune responses and inflammatory cytokine release [29, 30]

Activation of astrocytic mu-opioid receptor elicits fast glutamate release through TREK-1-containing K2P channel in hippocampal astrocytes

Bone-density measurements to predict fracture risk and define thresholds for prevention and treatment should be performed routinely in patients with IBD (Rogler 2004)