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Free Radical Biol Med 51:978992 Team RC (2013) R: A language and environment for statistical computing

These include positive regulators, such as ferredoxin 1 (FDX1) , lipoic acid synthase (LIAS) , lipotransferase 1 (LIPT1) , dihydrolipoamide dehydrogenase (DLD) , thiolipoamide S-acetyltransferase (DLAT) , pyruvate dehydrogenase E1 subunit 1 (PDHA1) , and pyruvate dehydrogenase E1 subunit (PDHB) , as well as negative regulators, like metal-responsive transcription factor-1 (MTF1) , glutaminase (GLS) , and cyclin-dependent kinase inhibitor 2 A (CDKN2A) [25]

Note that in many cases the density barrier enrichment of DCs is followed by further purification using antibody-bound beads 2

These findings highlight the importance of EAAT2 localization and trafficking for normal synaptic function, and provide a theoretical basis for novel pathophysiological mechanisms in neuropsychiatric diseases

Mitochondrial TCA cycle activity, fatty acid -oxidation, and amino acid metabolism contribute to ROS generation that, in concert with iron, amplify LP and drive ferroptotic signaling ( Figure 1 Morphologically, ferroptosis diverges from classical apoptosis and necrosis