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In glioblastoma, PHGDH binds to and stabilizes the transcription factor FOXM1, sustaining the expression of downstream targets (e.g., VEGF, CCND1, CHK2, and MMP-2 ) to drive glioma cell proliferation, invasion, and tumorigenicity [113] (Fig

Knockdown of endogenous GPX4 or blockade of GPX4 using a specific inhibitor enhanced the chemosensitivity of EBV-infected NPC cells

Signs and symptoms are more intense when the interval between the use of radiotherapy and the chemical trigger is shorter.28 There seems to be a radiation dose threshold that must be reached for recall dermatitis to develop

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Functional redundancy is most common for micronutrients, including many metal ions, where deficiency of one element may be compensated by substitution with another (Merchant & Helmann, 2012)