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Dimethyl fumarate (DMF) and its metabolite monomethyl fumarate (MMF) modulate some signaling proteins activity and intracellular concentration, such as the nuclear factor (erythroid-derived 2)-like 2 (Nrf2), nuclear factor-kappa B (Nf-B), and cyclic adenosine monophosphate

Several studies have proved the clinical efficacy of Doxil, where improved tumor response rates and a favorable safety profile were observed compared to the conventional formulation of doxorubicin

10.3389/fphar.2014.00097 222 PiacentiniR.Li PumaD

J Proteome Res 15:31083117 Leonard MM, Bai Y, Serena G, Nickerson KP, Camhi S, Sturgeon C, Yan S, Fiorentino MR, Katz A, Nath B et al (2019) RNA sequencing of intestinal mucosa reveals novel pathways functionally linked to celiac disease pathogenesis