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The production of ROMs is increased significantly in PD due to mitochondrial energy crisis, aging, neuroinflammation, high levels of iron or Ca 2+ , and GSH depletion (Meiser et al., 2013)

Funding This work was supported by grants from the National Natural Science Foundation of China (No.82072699)

Additionally, proteins are the second abundant nutrient in mushroom which upon fermentation are denatured owing to enzymatic break down of proteins, and nucleic acids producing biogenic amines, which can survive after blanching (Jaboska-Ry et al., 2019a, 2019b, 2019c, 2019d)