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Great strides have recently been made in achieving a molecular understanding of these sulfur species, which participate in various physiological and pathological pathways

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TFR1 recently has been introduced as a specific ferroptosis marker ( 3+ is reduced to Fe 2+ by the ferrireductase activity of six-transmembrane epithelial antigens of the prostate 3 (STEAP3) in the endosome (Knutson, 2007)

Further translational research is needed to determine to which degree peripheral markers reflect central mechanisms in order to establish clinically useful peripheral biomarkers