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Elevated production of ROS in C9orf72-associated ALS is also associated with abnormalities in mitochondrial function and neuroinflammation (Briehl et al., 80 DPRs interact with Atp5a1, which compromises mitochondrial functions in mice due to increased ROS production (Choi et al., 2019)

Siraki AG (2021) The many roles of myeloperoxidase: from inflammation and immunity to biomarkers, drug metabolism and drug discovery

Doseresponse analysis further indicated a statistically significant augmentation in mortality risk at doses above 150 IU/day (27)