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Research utilizing a mouse model of chronic iron overload has demonstrated that excess iron acts as a ROS stimulant, thereby exacerbating mitochondrial damage [97]

2.3 Targeting antioxidant signaling pathways 2.3.1 Nrf2 endogenous antioxidant pathway The Nrf2 endogenous antioxidant pathway is a natural system in the body that helps combat free radicals

Vollenweider et al., 2010)

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