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The Grade Working Group

Table 4 provides details on the risk of bias assessment for each study

Evidence suggests that pregnant women who receive folic acid supplementation may be at decreased risk for congenital neural tube defects in their offspring compared to pregnant women not receiving folic acid

Moreover, a large number of older patients living with chronic symptoms might not benefit from SMN-inducing treatments

Taking into account their aforementioned anti-autoimmunity and anti-cancer (including TC) properties, the omega-3 PUFA would be appropriate nutraceuticals to be used, either alone or combined with other supplements