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Metabolomics 21 (1), 1

From the perspective of nanotherapeutic intervention, the most actionable pathological mechanisms in epilepsy include excitationinhibition imbalance, GABAergic and glutamatergic dysregulation, circuit hyperexcitability, synaptic dysfunction, neuroinflammation, oxidative stress, and ion-channel-related abnormalities (Table 10) [136]