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Lifelong endurance training (more than 3 times/week) lower DNA methylation in 714 gene promoters, including those associated with glycolysis, glycogen metabolism, muscular dystrophies, and oxidative stress response in skeletal muscle of the elderly, potentially enhancing the expression of genes involved in muscle metabolism and myogenesis, while the methylation levels of introns, CpG islands and exons appear similar between physically active and inactive groups [132]

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Furthermore, no studies to date have reported pharmacokinetic parameters (e.g., absorption, bioavailability, tissue distribution), nor have they conducted long-term toxicity assessments or evaluated reproductive outcomes in vivo

Exp Biol Med (Maywood) (2008) 233:67488

BPC-157 is commonly administered via subcutaneous injection or oral formulation