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Antioxidant - a compound that prevents or repairs the damage caused by reactive oxygen species Antioxidant enzymes - enzymes that contribute to neutralizing atoms or molecules capable of damaging essential cell constituents Atherosclerosis - the buildup of plaque inside arterial walls Coronary - referring to the heart and especially the vessels that supply blood to the heart Inverse association - a relationship between two variables in which they move in opposite directions Ischemia - inadequate blood supply to an organ or tissue Observational study - a human research study in which no experimental intervention or treatment is applied, and participants are simply observed over time Oxidative stress - a situation in which the production of reactive oxygen species exceeds the ability of an organism to eliminate or neutralize them Placebo - a chemically inactive substance Plaque - a deposit of fat, cholesterol, immune cells, fibrin (a blood clotting protein), and other substances that forms inside arterial walls

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doi: 10.1002/art.41511 14 MorandEPikeMMerrillJTvan VollenhovenRWerthVPHobarCet al

Genetic testing, prompted by the patients visual disturbances and anemia, revealed an SLC19A2 gene mutation, thus confirming a diagnosis of TRMA

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