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Materials and methods Study design This multicenter retrospective cohort study including patients with confirmed COVID-19 infection was conducted during the first wave of the COVID-19 outbreak, between March and May 2020, when Italy was in strict lockdown

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By contrast, the stress sensor GADD45 was detected within only early differentiating IRS cells (supplementary figure 3c), while the ROS-protective protein heme oxygenase-1 (HO-1) was intensely expressed in a small subset of IRS cells located usually in the upper follicle, at the level of the sebaceous gland, where IRS cornification is advanced to complete (supplementary figures 3g and 3h)