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1111 Methotrexate should be used with extreme caution in patients with infection, peptic ulcer, ulcerative colitis, or debility, and in very young or geriatric patients

361 SAM enhances the levels of autophagy markers beclin-1 and LC3B-II in MCF-7 breast cancer cells and significantly increases the Bax/Bcl-2 ratio, indicating that SAM can inhibit breast cancer by inducing autophagy and apoptosis in MCF-7 cells

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