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Body composition changes typically become measurable at 8 to 12 weeks, with improvements continuing over 4 to 6 months

All data were indexed, scaled and subsequently integrated with Xia2 Dials

Generally mild and reversible with dose reduction or discontinuation

These findings suggest that ionophore-mediated Cu delivery to the intracellular compartment might be a promising therapeutic strategy for a subset of tumors, and additional Cuionophore complexes that target cuproptosis warrant further development

Never give methylcobalamin (vitamin B12) injection intravenously without checking the patients serum potassium levels first