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North EJ, Halden RU

569:23 6 Hongu N, DS

= 10 weeks)

Prion diseases are another type of fatal neurodegenerative disease that starts with the misfolding of the cellular prion protein (PrP C )normally involved in signal transduction (Didonna 2013)which in the disease state instead aggregates and accumulates

In addition to enzymatic L-lactylation utilizing lactate as a lactyl donor and involving enzymes including writers (lactyltransferases), readers (lactylation-binding enzymes), erasers (delactylases), and lactyl-coenzyme A (lactyl-CoA) synthases, non-enzymatic D-lactylation derived from the glyoxalase II substrate S-D-lactoylglutathione (SLG) has also been identified