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Without NAD+, your mitochondriathe powerhouses of your cellscannot function

doi: 10.1073/pnas.1603244113 16 XuTDingWJiXAoXLiuYYuWet al

elegans PD model treated with decanoic acid

"There is no other drug on the market that had that sort of safety record," Tatem said

Consistently, the mitochondrial mutants nuo-6 and isp-1 , which exhibit significant transcriptomic overlap with worms fed FAT-7-suppressing diets, also activate the UPRmt, and their lifespan extension depends on this pathway (Wu et al, 2018)