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They can also watch for rarer, more dangerous risks, such as gallbladder inflammation, gallstones, and pancreatitis

& Jellema, R

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This metabolic sensing function extends to regulation of key metabolic enzymes such as pyruvate dehydrogenase kinase, which is inhibited by low NAD+/NADH ratios, and lactate dehydrogenase, which is activated by high NADH levels, demonstrating the sophisticated regulatory networks that depend on NAD+ redox status

Thus, caution is advised when considering EGCG supplements for diabetic patients, particularly at high doses