If you're in a risk group and experiencing mood symptoms alongside fatigue, brain fog, or neurological changes, getting your B12 checked might be the single most actionable step available to you right now
B12 deficiency is significantly more common in India than in most Western populations, affecting an estimated 47-70% of vegetarians and a substantial proportion of the general population due to dietary patterns
Pharmacokinetics: Cyanocobalamin is administered intranasally, orally, and parenterally, while hydroxocobalamin is administered only parenterally. Once absorbed, vitamin B12 is highly bound to transcobalamin II, a specific B-globulin carrier protein and is distributed and stored primarily in the liver as coenzyme B12. The bone marrow also stores a significant amount of the absorbed vitamin B12. This vitamin crosses the placenta and is distributed into breast milk. Enterohepatic recirculation conserves systemic stores. The half-life is about 6 days (400 days in the liver). Elimination is primarily through the bile; however, excess cyanocobalamin is excreted unchanged in the urine
Grass-dominated pastures pose more of a risk for deficiency
Factors such as initial B12 levels, underlying medical conditions, certain medications, advanced age, and injection frequency can affect the absorption and utilization of B12, possibly shortening the duration of action